Stroke is the leading cause of disability globally and the second leadingvaginal infection cause of death in China, with ischemic stroke accounting for 86% of all strokes. Its high incidence imposes a serious burden on society. Chinese medicine ginseng is the root of the plant ginseng of the five-plus family, which has the effect of tonifying vitality, tonifying the spleen and benefiting the lungs, and calming the spirit. Here, we investigate the role of ginseng in mouse ischemic stroke models as well as the mechanism of action. Ginseng extract gavage was performed 24h after mouse MCAO(I/R)(Middle Cerebral Artery Occlusion and Reperfusion) modeling, and administered continuouslyselleck化学 for 3 days. After 3 days, the area of cerebral infarction decreased, the permeability of the blood-brain barrier deMC3体外creased, and the tight junction protein Claudin-5(closed protein-5), Occludin, and ZO-1(closed small cyclin 1) decreased. At the same time, the expression of pro-inflammatory factors IL-1β, TNF-α and IL-6 decreased. Therefore, we conclude that ginseng may increase the structure and function of the blood-brain barrier after acute stroke by reducing the inflammatory response.